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NPAS4 Gene Could be Key to Linking Long-Term Stress and Depression

The NPAS4 gene may play a critical role in linking long-term stress to depression and depressive behaviors. The findings may lead to new, targeted treatments for depression as a result of chronic stress.

NPAS4 Gene Could be Key to Linking Long-Term Stress and Depression
Draw an image in van gough and Théo Rysselberghe style. Category is Health and Title of the image is NPAS4 Gene Could be Key to Linking Long-Term Stress and Depression

Researchers at the Medical University of South Carolina have identified a gene, known as NPAS4, that may be key to explaining why long-term stress can lead to depression. In their study, published in the Journal of Neuroscience, the team found that the expression of the NPAS4 gene decreased in the prefrontal cortex of mice exposed to chronic stress. This decrease resulted in reduced synaptic plasticity, which could contribute to depressive symptoms. The findings of this study may pave the way for the development of new, targeted treatments for people with depression related to chronic stress.

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