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New Insights into Utilization of Nanotechnology-Based Drugs

Scientists at the Max Planck Institute for Polymer Research have now followed the path of nanoparticles into a cell using a combination of several microscopy methods and were able to observe a cell-internal process that effectively separates blood components and nanoparticles.

Nanoparticles are a current field of research and are used in modern medicine to effectively deliver active ingredients to where they are needed. While traveling through the bloodstream, blood proteins accumulate on the surface of the nanotransporter. Scientists have now been able to show that these can be separated again by processes in the cell. To observe this process, the researchers labelled a nanoparticle and blood proteins with different fluorescent dyes and used a combination of high-resolution light and electron microscopy. It was observed that the protein coating detaches from the nanoparticle and releases it, while the proteins were found in the cell membrane and the lysosomes. The nanoparticles were located in the endosomes, which are formed for the purpose of transporting substances into the cell.

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